Converging on a Cure: The Roads to Predictive Immunotherapy-Reference-Cited by-同舟云学术

Converging on a Cure: The Roads to Predictive Immunotherapy

Published:2023-04-17 Issue:5 Volume:13 Page:1053-1057
ISSN:2159-8274
Container-title:Cancer Discovery
language:en
Short-container-title:

Author:

Stein-O'Brien Genevieve L.¹²³⁴⁵^ORCID,Le Dung T.¹³⁶^ORCID,Jaffee Elizabeth M.¹³⁶^ORCID,Fertig Elana J.¹²⁶⁷⁸^ORCID,Zaidi Neeha¹³⁶^ORCID

Affiliation:

1. 1Johns Hopkins Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

2. 2Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

3. 3Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.

4. 4Kavli Neurodiscovery Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

5. 5Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland.

6. 6Johns Hopkins Bloomberg-Kimmel Institute for Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.

7. 7Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.

8. 8Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, Maryland.

Abstract

Summary: Convergence science teams integrating clinical, biological, engineering, and computational expertise are inventing new forecast systems to monitor and predict evolutionary changes in tumor and immune interactions during early cancer progression and therapeutic response. The resulting methods should inform a new predictive medicine paradigm to select adaptive immunotherapeutic regimens personalized to patients’ tumors at a given time during their cancer progression for durable patient response.

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology

Link

https://aacrjournals.org/cancerdiscovery/article-pdf/doi/10.1158/2159-8290.CD-23-0277/3293900/cd-23-0277.pdf

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