Covalent Rescue of Mutant p53-Reference-Cited by-同舟云学术

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Covalent Rescue of Mutant p53

Published:2023-01-09 Issue:1 Volume:13 Page:14-16
ISSN:2159-8274
Container-title:Cancer Discovery
language:en
Short-container-title:

Author:

Lane David P.¹^ORCID,Verma Chandra S.²³⁴^ORCID

Affiliation:

1. 1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet – Biomedicum, Solnavägen 9, Solna, Sweden.

2. 2Bioinformatics Institute (A*STAR), Singapore.

3. 3School of Biological Sciences, Nanyang Technological University, Singapore.

4. 4Department of Biological Sciences, National University of Singapore, Singapore.

Abstract

Summary: p53 mutant proteins are widely expressed in human cancer. In this issue, Guiley and Shokat describe the development of compounds that rescue the function of the Y220C mutant p53 protein by forming covalent complexes with the target protein. See related article by Guiley and Shokat, p. 56 (3).

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology

Link

https://aacrjournals.org/cancerdiscovery/article-pdf/13/1/14/3238179/14.pdf

Reference10 articles.

1. Integrated analysis of TP53 gene and pathway alterations in The Cancer Genome Atlas;Donehower;Cell Rep,2019

2. Li-Fraumeni syndrome: cancer risk assessment and clinical management;McBride;Nat Rev ClinOncol,2014

3. A small molecule reacts with the p53 somatic mutant Y220C to rescue wild-type thermal stability;Guiley;Cancer Discov,2023

4. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions;Ostrem;Nature,2013

5. Sotorasib for lung cancers with KRAS p.G12C mutation;Skoulidis;N Engl J Med,2021

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