BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition-Reference-Cited by-同舟云学术

BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition

Published:2020-08-19 Issue:1 Volume:11 Page:142-157
ISSN:2159-8274
Container-title:Cancer Discovery
language:en
Short-container-title:Cancer Discov

Author:

Hofmann Marco H.^ORCID,Gmachl Michael,Ramharter Juergen,Savarese Fabio,Gerlach Daniel^ORCID,Marszalek Joseph R.,Sanderson Michael P.,Kessler Dirk^ORCID,Trapani Francesca,Arnhof Heribert,Rumpel Klaus,Botesteanu Dana-Adriana,Ettmayer Peter^ORCID,Gerstberger Thomas,Kofink Christiane^ORCID,Wunberg Tobias^ORCID,Zoephel Andreas,Fu Szu-Chin,Teh Jessica L.^ORCID,Böttcher Jark^ORCID,Pototschnig Nikolai,Schachinger Franziska^ORCID,Schipany Katharina,Lieb Simone,Vellano Christopher P.,O'Connell Jonathan C.,Mendes Rachel L.,Moll Jurgen,Petronczki Mark^ORCID,Heffernan Timothy P.^ORCID,Pearson Mark,McConnell Darryl B.^ORCID,Kraut Norbert^ORCID

Funder

Boehringer Ingelheim and the Austrian Research Promotion Agency

the MDACC Science Park NGS Core

NCI

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology

Cited by 218 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Annual review of PROTAC degraders as anticancer agents in 2022;European Journal of Medicinal Chemistry;2024-03

2. Multiple medicinal chemistry strategies of targeting KRAS: State-of-the art and future directions;Bioorganic Chemistry;2024-03

3. A Potent SOS1 PROTAC Degrader with Synergistic Efficacy in Combination with KRAS^G12C Inhibitor;Journal of Medicinal Chemistry;2024-02-05

4. Deciphering the role of KRAS gene in oncogenesis: Focus on signaling pathways, genetic alterations in 3’UTR, KRAS specific miRNAs and therapeutic interventions;Critical Reviews in Oncology/Hematology;2024-02

5. Inhibition of the RAF/MEK/ERK Signaling Cascade in Pancreatic Cancer: Recent Advances and Future Perspectives;International Journal of Molecular Sciences;2024-01-28