Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in overcoming targeted therapy dosage challenges

Author:

Song Kai,Minami Jenna K,Huang ArthurORCID,Dehkordi Siavash R,Lomeli Shirley HORCID,Luebeck JensORCID,Goodman Mark H,Moriceau Gatien,Krijgsman OscarORCID,Dharanipragada Prashanthi,Ridgley TrevorORCID,Crosson William P,Salazar Jesus,Pazol Eli,Karin GabrielORCID,Jayaraman Rachana,Balanis Nikolas G,Alhani Salwan,Sheu Kyle,ten Hoeve JohannaORCID,Palermo Amelia,Motika Stephen E,Senaratne T. Niroshi,Paraiso Kim H,Hergenrother Paul J,Rao P. Nagesh,Multani Asha S,Peeper Daniel SORCID,Bafna VineetORCID,Lo Roger S.,Graeber Thomas G.ORCID

Funder

Mary Tanner

Ressler Family Foundation

Maurizio Grimaldi

HHS | NIH | National Cancer Institute

V Foundation for Cancer Research

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Melanoma Research Alliance

HHS | NIH | NIH Office of the Director

W. M. Keck Foundation

UC | UCLA | Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles

UC | UCLA | Jonsson Comprehensive Cancer Center

NSF | MPS | Division of Chemistry

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology

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