Colorectal Cancer Genomics by Genetic Ancestry-Reference-Cited by-同舟云学术

Colorectal Cancer Genomics by Genetic Ancestry

Published:2022-05-02 Issue:5 Volume:12 Page:1187-1188
ISSN:2159-8274
Container-title:Cancer Discovery
language:en
Short-container-title:

Author:

Eng Cathy¹,Holowatyj Andreana N.²^ORCID

Affiliation:

1. 1Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.

2. 2Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.

Abstract

Summary: Understanding molecular features of colorectal cancer across diverse populations is an indispensable step toward reducing the pronounced disparities in this disease burden. Based on the findings that individuals of African ancestry have an observed increase in the frequency of KRAS, AOC, and PIK3CA mutations, Myer and colleagues suggest that patients of African ancestry should consider treatment and clinical trials specific to these mutations. See related article by Myer et al., p. 1282 (2).

Funder

NIH

American Cancer Society

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology

Link

https://aacrjournals.org/cancerdiscovery/article-pdf/12/5/1187/3117230/1187.pdf

Reference9 articles.

1. Gut instinct: a call to study the biology of early-onset colorectal cancer disparities;Holowatyj;Nat Rev Cancer,2021

2. The genomics of colorectal cancer in populations with African and European ancestry;Myer;Cancer Discov,2022