A New Paradigm of the Origins of Circulating DNA in Patients with Cancer-Reference-Cited by-同舟云学术

A New Paradigm of the Origins of Circulating DNA in Patients with Cancer

Published:2023-10-05 Issue:10 Volume:13 Page:2122-2124
ISSN:2159-8274
Container-title:Cancer Discovery
language:en
Short-container-title:

Author:

Thierry Alain R.¹²^ORCID,Pisareva Ekaterina¹^ORCID

Affiliation:

1. 1IRCM, Montpellier Cancer Research Institute, INSERM U1194, Montpellier University, Montpellier, France.

2. 2ICM, Institut Régional du Cancer de Montpellier, Montpellier, France.

Abstract

Summary: By shedding light on the cellular origins of circulating DNA (cirDNA), this research provides important insights into the mechanisms of cirDNA production in cancer. Contrary to expectations, the increased cirDNA in patients with cancer was not derived predominantly from neoplastic cells or surrounding nonneoplastic epithelial cells; rather, the excess cirDNA originated primarily from leukocytes, implying a systemic impact of cancer on cell turnover or DNA clearance. See related article by Mattox et al., p. 2166 (1).

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology

Link

https://aacrjournals.org/cancerdiscovery/article-pdf/13/10/2122/3370151/2122.pdf

Reference10 articles.

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2. Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease;Moss;Nat Commun,2018

3. Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments;Sun;Proc Natl Acad Sci U S A,2015

4. Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin;Snyder;Cell,2016

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