Precision Oncology: 2023 in Review

Author:

Murciano-Goroff Yonina R.1,Suehnholz Sarah P.23,Drilon Alexander14,Chakravarty Debyani23

Affiliation:

1. 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

2. 2Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

3. 3Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

4. 4Weill Cornell Medical College, New York, New York.

Abstract

Summary: This article presents a review of recent major advances in precision oncology and the future implications of these advances, specifying the iterative progress achieved from the end of 2022 through 2023. We discuss the different classes of precision oncology drugs and associated biomarkers as well as the improvements in clinical trial design that have enabled the efficient testing of these drugs.

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology

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4. A first-in-human phase 1 study of LY3537982, a highly selective and potent KRAS G12C inhibitor in patients with KRAS G12C-mutant advanced solid tumors [abstract];Murciano-Goroff

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