Targeting the DHX9 RNA Helicase to Induce Antitumor Immunity in Small-Cell Lung Cancer-Reference-Cited by-同舟云学术

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Targeting the DHX9 RNA Helicase to Induce Antitumor Immunity in Small-Cell Lung Cancer

Published:2024-03-01 Issue:3 Volume:14 Page:389-391
ISSN:2159-8274
Container-title:Cancer Discovery
language:en
Short-container-title:

Author:

Chiappinelli Katherine B.¹²^ORCID

Affiliation:

1. 1Department of Microbiology, Immunology, & Tropical Medicine, The George Washington University, Washington D.C.

2. 2The GW Cancer Center, The George Washington University, Washington, D.C.

Abstract

Summary: Murayama and colleagues establish DHX9 as an exciting new target to induce viral mimicry and downstream antitumor immunity. The potential for use in combination with existing immune therapies is especially exciting in SCLC, an immunologically cold and deadly disease. See related article by Murayama et al., p. 468 (10) .

Publisher

American Association for Cancer Research (AACR)

Link

https://aacrjournals.org/cancerdiscovery/article-pdf/14/3/389/3419847/389.pdf

Reference11 articles.

1. Small-cell lung cancer;Rudin;Nat Rev Dis Primers,2021

2. Transposable element regulation and expression in cancer;Grundy;FEBS J,2022

3. Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses;Chiappinelli;Cell,2015

4. DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts;Roulois;Cell,2015

5. Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency;Mehdipour;Nature,2020

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