Affiliation:
1. 1Karmanos Cancer Institute/Department of Pathology, Wayne State University, Detroit MI;
2. 3Cancer Control Center of the Tachira State, San Cristobal, Venezuela, Venezuela
3. 2Unit of Field and Intervention Studies, IARC, Lyon, France; and
Abstract
Abstract
Although Helicobacter pylori (HP) infection has been acknowledged to play an etiological role in gastric carcinogenesis, its relatively weak association particularly in developing countries suggests critical roles of cofactors. Among a population with an extremely high prevalence of HP infection (≈95%) in Venezuela, we examined the relationship of household characteristics, smoking, alcohol drinking, dietary consumption, and plasma nutrient levels with the prevalence of three different stages of gastric precancerous lesions, chronic atrophic gastritis (AG; n = 337), intestinal metaplasia (IM; n = 551), and dysplasia (n = 157), in comparison with those without any of these lesions (n = 1154). Length of refrigerator use was marginally inversely associated with the prevalence of the precursor lesions studied. The association was most pronounced for AG followed by dysplasia. On the other hand, smoking status was a significant predictor for IM and dysplasia. Those smoking ≥10 cigarettes/day had 1.8-fold risk of IM and 3.6-fold risk of dysplasia compared with never smokers. There were no associations with alcohol consumption. When six food groups known to be associated with stomach cancer risk in Venezuela were tested, the prevalence of these lesions progressively increased with increasing starchy vegetable consumption and decreasing fresh fruit/fruit juice consumption. The association with fruits was more evident for dysplasia and AG and that with starchy vegetables for IM and AG. However, there were no inverse associations with plasma antioxidant vitamins. These findings offer important public health implications in preventing progression of HP-associated gastric precancerous lesions in high-risk populations.
Publisher
American Association for Cancer Research (AACR)
Reference53 articles.
1. Parkin DM, Pisani P, Ferlay, J. Estimate of the worldwide incidence of 25 major cancers in 1990. Int J Cancer, 1999;80:827–41.
2. IARC. IARC monographs on the evaluation of carcinogenic risks to humans. Vol 61. Schistosomes, liver flukes and Helicobacter pylori. Lyon: IARC; 1994.
3. Eslick GD, Lim LL-Y, Byles JE, Xia HH-X, Talley NJ. Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. Am J Gastroenterol, 1999;94:2372–9.
4. Correa P, Haenszel W, Cuello C, et al. The gastric precancerous process in a high risk population: cross-sectional studies. Cancer Res, 1990;50:4731–6.
5. Kuipers EJ, Uyterlinde AM, Pena AS, et al. Long-term sequelae of Helicobacter pylori gastritis. Lancet, 1995;345:1525–8.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献