Reproductive Factors Do Not Influence Survival with Ovarian Cancer-Reference-Cited by-同舟云学术

Reproductive Factors Do Not Influence Survival with Ovarian Cancer

Published:2022-01-21 Issue:4 Volume:31 Page:909-913
ISSN:1055-9965
Container-title:Cancer Epidemiology, Biomarkers & Prevention
language:en
Short-container-title:

Author:

Phung Minh Tung¹^ORCID,Alimujiang Aliya¹,Berchuck Andrew²,Anton-Culver Hoda³,Schildkraut Joellen M.⁴,Bandera Elisa V.⁵^ORCID,Chang-Claude Jenny⁶⁷^ORCID,Chase Anne⁸,Doherty Jennifer Anne⁹^ORCID,Grout Bronwyn⁸,Goodman Marc T.¹⁰¹¹,Hanley Gillian E.¹²,Lee Alice W.¹³^ORCID,McKinnon Deurloo Cindy⁸,Menon Usha¹⁴^ORCID,Modugno Francesmary¹⁵¹⁶¹⁷^ORCID,Pharoah Paul D.P.¹⁸¹⁹^ORCID,Pike Malcolm C.²⁰²¹^ORCID,Richardson Jean⁸²⁰^ORCID,Risch Harvey A.²²,Sieh Weiva²³²⁴^ORCID,Terry Kathryn L.²⁵²⁶,Webb Penelope M.²⁷^ORCID,Wentzensen Nicolas²⁸,Wu Anna H.²⁰,Pearce Celeste Leigh¹

Affiliation:

1. 1Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.

2. 2Division of Gynecologic Oncology, Duke University School of Medicine, Durham, North Carolina.

3. 3Department of Medicine, University of California Irvine, Irvine, California.

4. 4Emory University Rollins School of Public Health, Atlanta, Georgia.

5. 5Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.

6. 6Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.

7. 7Cancer Epidemiology Group, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

8. 8Patient Advocate.

9. 9Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.

10. 10Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, California.

11. 11Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.

12. 12Department of Obstetrics and Gynecology, University of British Columbia Faculty of Medicine, Vancouver, Canada.

13. 13Department of Public Health, California State University, Fullerton, Fullerton, California.

14. 14MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, UCL, London, United Kingdom.

15. 15Women's Cancer Research Center, Magee-Women's Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania.

16. 16Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

17. 17Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburg, Pennsylvania.

18. 18Department of Oncology, Center for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.

19. 19Department of Public Health and Primary Care, Center for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.

20. 20Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

21. 21Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.

22. 22Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.

23. 23Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.

24. 24Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

25. 25Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts.

26. 26Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

27. 27Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

28. 28Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Abstract

Abstract Background: Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes. Methods: Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian tube, or primary peritoneal cancer (ovarian cancer) from 16 studies in the Ovarian Cancer Association Consortium (OCAC), we examined the associations between survival and age at menarche, combined oral contraceptive use, parity, breastfeeding, age at last pregnancy, and menopausal status using Cox proportional hazard models. The models were adjusted for age at diagnosis, race/ethnicity, education level, and OCAC study and stratified on stage and histotype. Results: During the mean follow-up of 6.34 years (SD = 4.80), 6,418 patients passed away (57.4%). There was no evidence of associations between the reproductive factors and survival among patients with ovarian cancer overall or by histotype. Conclusions: This study found no association between reproductive factors and survival after an ovarian cancer diagnosis. Impact: Reproductive factors are well-established risk factors for ovarian cancer, but they are not associated with survival after a diagnosis of ovarian cancer.

Funder

Medical Research and Materiel Command

National Health & Medical Research Council of Australia

Cancer Foundation of Western Australia

NHMRC

German Federal Ministry of Education and Research

Program of Clinical Biomedical Research

Cancer Research UK

NIH

National Institutes of Health

Department of Defense

NCI