Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses-Reference-Cited by-同舟云学术

Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses

Published:2022-06-16 Issue:9 Volume:31 Page:1839-1848
ISSN:1055-9965
Container-title:Cancer Epidemiology, Biomarkers & Prevention
language:en
Short-container-title:

Author:

Dimou Niki¹^ORCID,Omiyale Wemimo²^ORCID,Biessy Carine¹^ORCID,Viallon Vivian¹^ORCID,Kaaks Rudolf³^ORCID,O'Mara Tracy A.⁴^ORCID,Aglago Elom K.¹^ORCID,Ardanaz Eva⁵⁶⁷^ORCID,Bergmann Manuela M.⁸^ORCID,Bondonno Nicola P.⁹^ORCID,Braaten Tonje¹⁰^ORCID,Colorado-Yohar Sandra M.⁷¹¹¹²^ORCID,Crous-Bou Marta¹³¹⁴^ORCID,Dahm Christina C.¹⁵^ORCID,Fortner Renée T.³^ORCID,Gram Inger T.¹⁰^ORCID,Harlid Sophia¹⁶^ORCID,Heath Alicia K.¹⁷^ORCID,Idahl Annika¹⁶^ORCID,Kvaskoff Marina¹⁸^ORCID,Nøst Therese H.¹⁰¹⁹^ORCID,Overvad Kim¹⁵^ORCID,Palli Domenico²⁰^ORCID,Perez-Cornago Aurora²¹^ORCID,Sacerdote Carlotta²²^ORCID,Sánchez Maria-Jose²³²⁴²⁵²⁶^ORCID,Schulze Matthias B.²⁷²⁸^ORCID,Severi Gianluca¹⁸²⁹^ORCID,Simeon Vittorio³⁰^ORCID,Tagliabue Giovanna³¹^ORCID,Tjønneland Anne³²^ORCID,Truong Thérèse¹⁸^ORCID,Tumino Rosario³³^ORCID,Johansson Mattias³⁴^ORCID,Weiderpass Elisabete³⁵^ORCID,Murphy Neil¹^ORCID,Gunter Marc J.¹^ORCID,Lacey Ben²^ORCID,Allen Naomi E.²^ORCID,Dossus Laure¹^ORCID

Affiliation:

1. 1Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.

2. 2Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

3. 3Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

4. 4Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

5. 5Navarra Public Health Institute, Pamplona, Spain.

6. 6IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.

7. 7CIBER Epidemiología y Salud Pública (CIBERESP), Spain.

8. 8German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.

9. 9Danish Cancer Society Research Center, Copenhagen, Denmark.

10. 10Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.

11. 11Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.

12. 12Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia.

13. 13Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

14. 14Department of Epidemiology, Harvard T.H. Chan School of Public Health. Boston, Massachusetts.

15. 15Department of Public Health, Aarhus University, Aarhus, Denmark.

16. 16Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Umeå, Sweden.

17. 17Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.

18. 18Université Paris-Saclay, UVSQ, Inserm CESP U1018, "Exposome and Heredity" Team, Gustave Roussy, Villejuif, France.

19. 19K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

20. 20Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.

21. 21Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

22. 22Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy.

23. 23Escuela Andaluza de Salud Pública (EASP), Granada, Spain.

24. 24Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.

25. 25Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

26. 26Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain.

27. 27Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.

28. 28Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.

29. 29Department of Statistics, Computer Science, Applications "G. Parenti", University of Florence, Florence, Italy.

30. 30Dipartimento di Salute Mentale e Fisica e Medicina Preventiva, University of Naples "L. Vanvitelli", Naples, Italy.

31. 31Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori Via Venezian 1, Milan, Italy.

32. 32Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

33. 33Hyblean Association for Epidemiological Research, AIRE-ONLUS, Ragusa, Italy.

34. 34Section of Genetics, International Agency for Research on Cancer, Lyon, France.

35. 35Office of the Director, International Agency for Research on Cancer, World Health Organization, Lyon, France.

Abstract

Abstract Background: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses. Methods: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined. Results: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91–1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer. Conclusions: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. Impact: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.

Funder

Institut National de la Santé et de la Recherche Médicale

Cancer Research UK

Medical Research Council

EPIC-Norfolk study

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology,Epidemiology

Link

https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-21-1176/3183940/epi-21-1176.pdf

Reference49 articles.