Marital Status, Living Arrangement, and Survival among Individuals with Advanced Prostate Cancer in the International Registry for Men with Advanced Prostate Cancer-Reference-Cited by-同舟云学术

Marital Status, Living Arrangement, and Survival among Individuals with Advanced Prostate Cancer in the International Registry for Men with Advanced Prostate Cancer

Published:2024-01-08 Issue:3 Volume:33 Page:419-425
ISSN:1055-9965
Container-title:Cancer Epidemiology, Biomarkers & Prevention
language:en
Short-container-title:

Author:

Chen Naiyu¹^ORCID,McGrath Colleen B.¹^ORCID,Ericsson Caroline I.¹^ORCID,Vaselkiv Jane B.¹^ORCID,Rencsok Emily M.¹²^ORCID,Stopsack Konrad H.¹³^ORCID,Guard Hannah E.¹^ORCID,Autio Karen A.⁴^ORCID,Rathkopf Dana E.⁴^ORCID,Enting Deborah⁵^ORCID,Bitting Rhonda L.⁶^ORCID,Mateo Joaquin⁷^ORCID,Githiaka Charles W.⁸^ORCID,Chi Kim N.⁹^ORCID,Cheng Heather H.¹⁰^ORCID,Davis Ian D.¹¹¹²^ORCID,Anderson Simon G.¹³¹⁴^ORCID,Badal Simone Ann Marie¹⁴¹⁵^ORCID,Bjartell Anders¹⁶^ORCID,Russnes Kjell M.¹⁷^ORCID,Heath Elisabeth I.¹⁸^ORCID,Pomerantz Mark M.¹⁹^ORCID,Henegan John C.²⁰^ORCID,Hyslop Terry²¹^ORCID,Esteban Emilio²²^ORCID,Omlin Aurelius²³^ORCID,McDermott Ray²⁴^ORCID,Fay Andre P.²⁵^ORCID,Popoola Ademola Alabi²⁶^ORCID,Ragin Camille¹⁴²⁷^ORCID,Nowak Joel²⁸^ORCID,Gerke Travis²⁹^ORCID,Kantoff Philip W.⁴^ORCID,George Daniel J.⁶^ORCID,Penney Kathryn L.¹³⁰^ORCID,Mucci Lorelei A.¹^ORCID,

Affiliation:

1. 1Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

2. 2Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts.

3. 3Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

4. 4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

5. 5Guy's and St. Thomas’ NHS Foundation Trust, London, United Kingdom.

6. 6Durham VA Health Care System, Durham, North Carolina.

7. 7Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital Campus, Barcelona, Spain.

8. 8Department of Surgery, University of Nairobi, Nairobi, Kenya.

9. 9BC Cancer, Vancouver, British Columbia, Canada.

10. 10University of Washington and Fred Hutchinson Cancer Center, Seattle, Washington.

11. 11Monash University Faculty of Medicine, Melbourne, Australia.

12. 12Eastern Health, Melbourne, Australia.

13. 13The Glasgow-Caribbean Centre for Development Research and the Caribbean Institute of Health Research, The University of the West Indies, Bridgetown, Barbados.

14. 14African–Caribbean Cancer Consortium, Philadelphia, Pennsylvania.

15. 15The University of the West Indies Mona, Kingston, Jamaica.

16. 16Department of Urology, Skåne University Hospital, Malmö, Sweden.

17. 17Department of Oncology, Oslo University Hospital, Oslo, Norway.

18. 18Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.

19. 19Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

20. 20Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.

21. 21Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

22. 22Department of Medical Oncology, Hospital Universitario Central of Asturias, ISPA, Oviedo, Spain.

23. 23OnkoZentrum, Zurich, Switzerland.

24. 24St Vincent's University Hospital and Cancer Trials Ireland, Dublin, Ireland.

25. 25PUCRS School of Medicine, Hospital Nora Teixeira, Porto Alegre, Brazil.

26. 26University of Ilorin, Ilorin, Nigeria.

27. 27Fox Chase Cancer Center, Philadelphia, Pennsylvania.

28. 28Cancer ABCs, Brooklyn, New York.

29. 29Prostate Cancer Clinical Trials Consortium, New York, New York.

30. 30Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Abstract

Abstract Background: Studies have shown improved survival among individuals with cancer with higher levels of social support. Few studies have investigated social support and overall survival (OS) in individuals with advanced prostate cancer in an international cohort. We investigated the associations of marital status and living arrangements with OS among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer (IRONMAN). Methods: IRONMAN is enrolling participants diagnosed with advanced prostate cancer (metastatic hormone-sensitive prostate cancer, mHSPC; castration-resistant prostate cancer, CRPC) from 16 countries. Participants in this analysis were recruited between July 2017 and January 2023. Adjusting for demographics and tumor characteristics, the associations were estimated using Cox regression and stratified by disease state (mHSPC, CRPC), age (<70, ≥70 years), and continent of enrollment (North America, Europe, Other). Results: We included 2,119 participants with advanced prostate cancer, of whom 427 died during up to 5 years of follow-up (median 6 months). Two-thirds had mHSPC. Most were married/in a civil partnership (79%) and 6% were widowed. Very few married participants were living alone (1%), while most unmarried participants were living alone (70%). Married participants had better OS than unmarried participants [adjusted HR: 1.44; 95% confidence interval (CI): 1.02–2.02]. Widowed participants had the worst survival compared with married individuals (adjusted HR: 1.89; 95% CI: 1.22–2.94). Conclusions: Among those with advanced prostate cancer, unmarried and widowed participants had worse OS compared with married participants. Impact: This research highlighted the importance of social support in OS within this vulnerable population.

Funder

National Cancer Institute

National Institute of General Medical Sciences

Publisher

American Association for Cancer Research (AACR)

Link

https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-23-1207/3401068/epi-23-1207.pdf

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