Hypertension and Risk of Endometrial Cancer: A Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium (E2C2)-Reference-Cited by-同舟云学术

Hypertension and Risk of Endometrial Cancer: A Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium (E2C2)

Published:2024-03-26 Issue:6 Volume:33 Page:788-795
ISSN:1055-9965
Container-title:Cancer Epidemiology, Biomarkers & Prevention
language:en
Short-container-title:

Author:

Habeshian Talar S.¹²^ORCID,Peeri Noah C.³^ORCID,De Vivo Immaculata⁴⁵^ORCID,Schouten Leo J.⁶^ORCID,Shu Xiao-ou⁷^ORCID,Cote Michele L.⁸^ORCID,Bertrand Kimberly A.⁹^ORCID,Chen Yu¹⁰^ORCID,Clarke Megan A.¹¹^ORCID,Clendenen Tess V.¹⁰^ORCID,Cook Linda S.¹²^ORCID,Costas Laura¹³¹⁴^ORCID,Dal Maso Luigino¹⁵^ORCID,Freudenheim Jo L.¹⁶^ORCID,Friedenreich Christine M.¹⁷^ORCID,Gallagher Grace³^ORCID,Gierach Gretchen L.¹⁸^ORCID,Goodman Marc T.¹⁹^ORCID,Jordan Susan J.²⁰^ORCID,La Vecchia Carlo²¹^ORCID,Lacey James V.²²^ORCID,Levi Fabio²³^ORCID,Liao Linda M.¹⁸^ORCID,Lipworth Loren²⁴^ORCID,Lu Lingeng²⁵^ORCID,Matias-Guiu Xavier²⁶^ORCID,Moysich Kirsten B.²⁷^ORCID,Mutter George L.²⁸^ORCID,Na Renhua²⁹^ORCID,Naduparambil Jeffin³^ORCID,Negri Eva³⁰^ORCID,O'Connell Kelli³^ORCID,O'Mara Tracy A.³¹^ORCID,Onieva Hernández Irene³²^ORCID,Palmer Julie R.³³^ORCID,Parazzini Fabio²¹^ORCID,Patel Alpa V.³⁴^ORCID,Penney Kathryn L.³⁵³⁶^ORCID,Prizment Anna E.³⁷^ORCID,Ricceri Fulvio³⁸^ORCID,Risch Harvey A.²⁵^ORCID,Sacerdote Carlotta³⁹^ORCID,Sandin Sven⁴⁰⁴¹^ORCID,Stolzenberg-Solomon Rachael Z.¹⁸^ORCID,van den Brandt Piet A.⁴²^ORCID,Webb Penelope M.⁴³^ORCID,Wentzensen Nicolas¹¹^ORCID,Wijayabahu Akemi T.¹¹^ORCID,Wilkens Lynne R.⁴⁴^ORCID,Xu Wanghong⁴⁵^ORCID,Yu Herbert⁴⁶^ORCID,Zeleniuch-Jacquotte Anne⁴⁷^ORCID,Zheng Wei⁷^ORCID,Du Mengmeng³^ORCID,Setiawan Veronica Wendy¹⁴⁸^ORCID

Affiliation:

1. 1Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.

2. 2Department of Research and Evaluation, Division of Health Services Research and Implementation Science, Kaiser Permanente Southern California, Pasadena, California.

3. 3Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.

4. 4Department of Epidemiology, Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts.

5. 5Medicine, Harvard Medical School, Boston, Massachusetts.

6. 6Department of Epidemiology, GROW-Research Institute for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, the Netherlands.

7. 7Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

8. 8Fairbanks School of Public Health, Department of Epidemiology, Indiana University Simon Comprehensive Cancer Center, Indianapolis, Indiana.

9. 9Slone Epidemiology Center, Boston University, Boston, Massachusetts.

10. 10Population Health, New York University School of Medicine, New York, New York.

11. 11Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland.

12. 12Epidemiology, Colorado School of Public Health, Aurora, Colorado.

13. 13Cancer Epidemiology Research Programme, Institut Català d'Oncologia, Barcelona, Spain.

14. 14Consortium for Biomedical Research in Epidemiology and Public Health - CIBERESP, Carlos III Institute of Health, Madrid, Spain.

15. 15Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.

16. 16Department of Epidemiology and Environmental Health, University at Buffalo, State University of New York, Buffalo, New York.

17. 17Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada.

18. 18Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

19. 19Cancer Prevention and Control Program, Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.

20. 20School of Public Health, University of Queensland, Herston, Queensland, Australia.

21. 21Department of Clinical Medicine and Community Health, University of Milan, Milan, Italy.

22. 22Department of Computational and Quantitative Medicine, City of Hope, Duarte, California.

23. 23Epidemiology and Health Services Research, University of Lausanne, Lausanne, Switzerland.

24. 24Department of Medicine, Vanderbilt University, Nashville, Tennessee.

25. 25Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.

26. 26Department of Pathology, University Hospital of Bellvitge, IDIBELL, Barcelona, Spain.

27. 27Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

28. 28Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

29. 29Population Health, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

30. 30Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

31. 31Cancer Research Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

32. 32Faculty of Medicine, Cancer Epidemiology Research Programme and University of Barcelona, Institut Català d'Oncologia, Barcelona, Spain.

33. 33Slone Epidemiology Center and Department of Medicine, Boston University, Boston, Massachusetts.

34. 34Population Science, American Cancer Society, Kennesaw, Georgia.

35. 35Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

36. 36Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts.

37. 37Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota.

38. 38Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.

39. 39Unit of Cancer Epidemiology, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, Turin, Italy.

40. 40Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

41. 41Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.

42. 42Epidemiology, Maastricht University, Maastricht, the Netherlands.

43. 43Population Health Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

44. 44Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, Hawaii.

45. 45Epidemiology, Fudan University School of Public Health, Shanghai, China.

46. 46Cancer Center, University of Hawaii, Honolulu, Hawaii.

47. 47Population health, New York University School of Medicine, New York, New York.

48. 48Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.

Abstract

Abstract Background: The incidence rates of endometrial cancer are increasing, which may partly be explained by the rising prevalence of obesity, an established risk factor for endometrial cancer. Hypertension, another component of metabolic syndrome, is also increasing in prevalence, and emerging evidence suggests that it may be associated with the development of certain cancers. The role of hypertension independent of other components of metabolic syndrome in the etiology of endometrial cancer remains unclear. In this study, we evaluated hypertension as an independent risk factor for endometrial cancer and whether this association is modified by other established risk factors. Methods: We included 15,631 endometrial cancer cases and 42,239 controls matched on age, race, and study-specific factors from 29 studies in the Epidemiology of Endometrial Cancer Consortium. We used multivariable unconditional logistic regression models to estimate ORs and 95% confidence intervals (CI) to evaluate the association between hypertension and endometrial cancer and whether this association differed by study design, race/ethnicity, body mass index, diabetes status, smoking status, or reproductive factors. Results: Hypertension was associated with an increased risk of endometrial cancer (OR, 1.14; 95% CI, 1.09–1.19). There was significant heterogeneity by study design (Phet < 0.01), with a stronger magnitude of association observed among case–control versus cohort studies. Stronger associations were also noted for pre-/perimenopausal women and never users of postmenopausal hormone therapy. Conclusions: Hypertension is associated with endometrial cancer risk independently from known risk factors. Future research should focus on biologic mechanisms underlying this association. Impact: This study provides evidence that hypertension may be an independent risk factor for endometrial cancer.

Funder

National Cancer Institute

Publisher

American Association for Cancer Research (AACR)

Link

https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-23-1444/3433658/epi-23-1444.pdf

Reference42 articles.

1. Differential trends in rising endometrial cancer incidence by age, race, and ethnicity;Liu;JNCI Cancer Spectr,2023

2. Increased incidence of endometrial cancer following the women's health initiative: an assessment of risk factors;Constantine;J Womens Health (Larchmt),2019

3. Hysterectomy-corrected uterine corpus cancer incidence trends and differences in relative survival reveal racial disparities and rising rates of nonendometrioid cancers;Clarke;J Clin Oncol,2019

4. Prevalence of obesity and severe obesity among adults: United States, 2017–2018;Hales;NCHS Data Brief,2020