From Hazard Rate to Age-at-Onset Distribution: Mind the Gap-Reference-Cited by-同舟云学术

From Hazard Rate to Age-at-Onset Distribution: Mind the Gap

Published:2023-09-12 Issue:11 Volume:32 Page:1477-1478
ISSN:1055-9965
Container-title:Cancer Epidemiology, Biomarkers & Prevention
language:en
Short-container-title:

Author:

Chatterjee Nilanjan¹²^ORCID,Dun Yuzheng¹^ORCID

Affiliation:

1. 1Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

2. 2Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland.

Abstract

Abstract A recent study published in the journal claimed that genetic susceptibility to breast cancer occurs mainly due to rare inherited variants. The claim relies on a set of deductive arguments following observations on patterns of age-at-onset distribution of the disease among twin pairs. In this brief commentary, we point out a major gap in the given argument due to the interchangeable use of hazard rates and age-at-onset distribution, and thus conclude that the published study does not provide any evidence against polygenic risk of breast cancer due to common variants. See related article by Yasui et al., p. 1518

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology,Epidemiology

Link

https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-23-0897/3364081/epi-23-0897.pdf

Reference9 articles.

1. Inference on the genetic architecture of breast cancer risk;Yasui;Cancer Epidemiol Biomarkers Prev,2023

2. Association analysis identifies 65 new breast cancer risk loci;Michailidou;Nature,2017

3. Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses;Zhang;Nat Genet,2020

4. Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers;Zhang;Nat Commun,2020

5. Rare variants create synthetic genome-wide associations;Dickson;PLoS Biol,2010