Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants-Reference-Cited by-同舟云学术

Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants

Published:2022-07-06 Issue:9 Volume:31 Page:1727-1734
ISSN:1055-9965
Container-title:Cancer Epidemiology, Biomarkers & Prevention
language:en
Short-container-title:

Author:

Jang Jieun¹²³^ORCID,Lee Sangjun¹²³^ORCID,Ko Kwang-Pil⁴^ORCID,Abe Sarah K.⁵^ORCID,Rahman Md. Shafiur⁵⁶^ORCID,Saito Eiko⁷^ORCID,Islam Md. Rashedul⁵⁸^ORCID,Sawada Norie⁹^ORCID,Shu Xiao-Ou¹⁰^ORCID,Koh Woon-Puay¹¹¹²^ORCID,Sadakane Atsuko¹³^ORCID,Tsuji Ichiro¹⁴^ORCID,Kim Jeongseon¹⁵^ORCID,Oze Isao¹⁶^ORCID,Nagata Chisato¹⁷^ORCID,Tsugane Shoichiro⁹^ORCID,Cai Hui¹⁰^ORCID,Yuan Jian-Min¹⁸¹⁹^ORCID,Gao Yu-Tang²⁰^ORCID,Ozasa Kotaro¹³^ORCID,Matsuyama Sanae¹⁴^ORCID,Kanemura Seiki¹⁴^ORCID,Shin Aesun¹²²¹^ORCID,Ito Hidemi²²²³^ORCID,Wada Keiko¹⁷^ORCID,Sugawara Yumi¹⁴^ORCID,Chen Yu²⁴^ORCID,Ahsan Habibul²⁵^ORCID,Boffetta Paolo²⁶²⁷^ORCID,Chia Kee Seng²⁸^ORCID,Matsuo Keitaro¹⁶²⁹^ORCID,Qiao You-Lin³⁰^ORCID,Rothman Nathaniel³¹^ORCID,Zheng Wei¹⁰^ORCID,Inoue Manami⁵^ORCID,Kang Daehee¹²²⁰^ORCID,Park Sue K.¹²²⁰^ORCID

Affiliation:

1. 1Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.

2. 2Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

3. 3Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.

4. 4Clinical Preventive Medicine Center, Seoul National University Bundang HospitaI, Seongnam-si, Gyeonggi-do, Korea.

5. 5Division of Prevention, National Cancer Center Institute for Cancer Control, Japan.

6. 6Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.

7. 7Institute for Global Health Policy Research, National Center for Global Health and Medicine, Tokyo, Japan.

8. 8Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

9. 9Epidemiology and Prevention Group, National Cancer Center Institute for Cancer Control, Tokyo, Japan.

10. 10Division of Epidemiology, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, Tennessee.

11. 11Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

12. 12Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore.

13. 13Radiation Effects Research Foundation, Hiroshima, Japan.

14. 14Tohoku University Graduate School of Medicine, Miyagi Prefecture, Japan.

15. 15Graduate School of Science and Policy, National Cancer Center, Goyang, Korea.

16. 16Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.

17. 17Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

18. 18Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania.

19. 19Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.

20. 20State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.

21. 21Integrated Major in Innovative Medical Science, Seoul National University College of Medicine, Seoul, Korea.

22. 22Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.

23. 23Division of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

24. 24Departments of Population Health and Environmental Medicine, New York University School of Medicine, New York, New York.

25. 25Department of Public Health Sciences, University of Chicago, Illinois.

26. 26Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York.

27. 27Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

28. 28Saw Swee Hock School of Public Health, National University of Singapore, Singapore.

29. 29Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

30. 30Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

31. 31Division of Cancer Epidemiology & Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland.

Abstract

Abstract Background: This study was performed to investigate the association between body mass index (BMI) and gastric cancer in East and Southeast Asia where most of gastric cancer is non-cardia gastric cancer. Methods: On the basis of 8,997 gastric cancer cases among the Asia Cohort Consortium participants from China, Japan, Korea, and Singapore (N = 538,835), we assessed gastric cancer risk according to BMI by calculating hazard ratios (HR) and 95% confidence intervals (CI) using the Cox proportional hazard regression model. Results: A U-shaped associations between BMI and gastric cancer risk were observed. Gastric cancer risks in underweight group (<18.5 kg/m2) and in obesity group (≥27.5 kg/m2) were higher than reference BMI group (23–24.9 kg/m2; HR, 1.15; 95% CI, 1.05–1.25 for underweight; HR, 1.12; 95% CI, 1.03–1.22 for obesity, respectively). The associations of underweight and obesity with gastric cancer risk were consistent in the analyses for non-cardia gastric cancer, intestinal-type gastric cancer, and late-onset gastric cancer. No significant association of underweight and obesity with the risk of cardia gastric cancer, diffuse-type gastric cancer, and early-onset gastric cancer was observed. In addition, we found that the U-shaped association between BMI and gastric cancer risk remained in nonsmokers, while only underweight was related to increased gastric cancer risk in smokers. Conclusions: BMI has a U-shaped association with gastric cancer risk in East and Southeast Asian population, especially for the non-cardia gastric cancer, intestinal-type gastric cancer, and late-onset gastric cancer. Impact: Future studies with consideration of anatomic location and histology of gastric cancer are needed to establish the association of underweight as well as obesity with gastric cancer risk.

Funder

Korea government

US NCI

National Cancer Center Research and Development

National Cancer Center Research and Development of Korea

National Cancer Center Research and Development Fund

Publisher

American Association for Cancer Research (AACR)

Subject

Oncology,Epidemiology

Link

https://aacrjournals.org/cebp/article-pdf/doi/10.1158/1055-9965.EPI-22-0051/3179159/epi-22-0051.pdf