Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response-Reference-Cited by-同舟云学术

Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response

Published:2023-11-03 Issue:1 Volume:84 Page:9-16
ISSN:0008-5472
Container-title:Cancer Research
language:en
Short-container-title:

Author:

Ramos Louise¹²^ORCID,Henriksson Martin³^ORCID,Helleday Thomas¹³^ORCID,Green Alanna C.¹⁴^ORCID

Affiliation:

1. 1Weston Park Cancer Centre and Division of Clinical Medicine, School of Medicine and Population Health, Faculty of Health, University of Sheffield, Sheffield, United Kingdom.

2. 2Vancouver Prostate Centre and Department of Experimental Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

3. 3Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.

4. 4Mellanby Centre for Bone Research, University of Sheffield Medical School, University of Sheffield, Sheffield, United Kingdom.

Abstract

Abstract The one-carbon folate enzyme methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 (MTHFD2) is a promising therapeutic target in cancer. MTHFD2 is upregulated across numerous cancer types, promotes growth and metastasis of cancer, and correlates with poorer survival. Recent studies have developed small-molecule inhibitors to the isozymes MTHFD2 and MTHFD1 that show promise as anticancer agents through different mechanisms. This review discusses the current understanding of the function of MTHFD2 in cancer and the status of inhibitors for treating MTHFD2-overexpressing cancers.

Funder

Sheffield Hospitals Charity

Blood Cancer UK

University of Sheffield

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/cancerres/article-pdf/doi/10.1158/0008-5472.CAN-23-1290/3380705/can-23-1290.pdf

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