The Genetic Evolution of Metastasis-Reference-Cited by-同舟云学术

The Genetic Evolution of Metastasis

Published:2022-04-26 Issue:10 Volume:82 Page:1849-1857
ISSN:0008-5472
Container-title:Cancer Research
language:en
Short-container-title:

Author:

Rogiers Aljosja¹²^ORCID,Lobon Irene¹^ORCID,Spain Lavinia¹³⁴⁵^ORCID,Turajlic Samra¹²⁶^ORCID

Affiliation:

1. Cancer Dynamics Laboratory, The Francis Crick Institute, London, United Kingdom.

2. Renal and Skin Units, The Royal Marsden NHS Foundation Trust, London, United Kingdom.

3. Medical Oncology Department, Peter MacCallum Cancer Centre, Melbourne, Australia.

4. Medical Oncology Department, Eastern Health, Melbourne Australia.

5. Eastern Health Clinical School, Monash University, Box Hill, Australia.

6. Melanoma and Kidney Cancer Team, The Institute of Cancer Research, London, United Kingdom.

Abstract

Abstract Cancer is an evolutionary process that is characterized by the emergence of multiple genetically distinct populations or clones within the primary tumor. Intratumor heterogeneity provides a substrate for the selection of adaptive clones, such as those that lead to metastasis. Comparative molecular studies of primary tumors and metastases have identified distinct genomic features associated with the development of metastases. In this review, we discuss how these insights could inform clinical decision-making and uncover rational antimetastasis treatment strategies.

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/cancerres/article-pdf/doi/10.1158/0008-5472.CAN-21-3863/3119020/can-21-3863.pdf

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