The Central Role of mTORC1 in Amino Acid Sensing-Reference-Cited by-同舟云学术

The Central Role of mTORC1 in Amino Acid Sensing

Published:2022-06-24 Issue:17 Volume:82 Page:2964-2974
ISSN:0008-5472
Container-title:Cancer Research
language:en
Short-container-title:

Author:

Yue Shusheng¹,Li Guanya¹,He Shanping¹,Li Tingting¹^ORCID

Affiliation:

1. 1State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, China.

Abstract

Abstract The mTOR is a master regulator of cell growth that controls cell homeostasis in response to nutrients, growth factors, and other environmental cues. Recent studies have emphasized the importance of lysosomes as a hub for nutrient sensing, especially amino acid sensing by mTORC1. This review highlights recent advances in understanding the amino acid–mTORC1 signaling axis and the role of mTORC1 in cancer.

Funder

National Natural Science Foundation of China

Natural Science Foundation for Outstanding Young Scholars of Hunan Province

Hunan Science and Technology Project

Key R&D Program of Hunan Province

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/cancerres/article-pdf/doi/10.1158/0008-5472.CAN-21-4403/3164462/can-21-4403.pdf

Reference141 articles.