The Mechanisms of Action of Tumor Treating Fields-Reference-Cited by-同舟云学术

The Mechanisms of Action of Tumor Treating Fields

Published:2022-07-15 Issue:20 Volume:82 Page:3650-3658
ISSN:0008-5472
Container-title:Cancer Research
language:en
Short-container-title:

Author:

Moser Justin C.¹²^ORCID,Salvador Ellaine³^ORCID,Deniz Karina⁴,Swanson Kenneth⁵,Tuszynski Jack⁶^ORCID,Carlson Kristen W.⁷,Karanam Narasimha Kumar⁸,Patel Chirag B.⁹¹⁰^ORCID,Story Michael⁸^ORCID,Lou Emil⁴^ORCID,Hagemann Carsten³^ORCID

Affiliation:

1. 1HonorHealth Research and Innovation Institute, Scottsdale, Arizona.

2. 2Department of Medicine, University of Arizona College of Medicine- Phoenix, Phoenix, Arizona.

3. 3Section Experimental Neurosurgery, Department of Neurosurgery, University of Würzburg, Würzburg, Germany.

4. 4Department of Medicine, Division of Hematology Oncology and Transplant, University of Minnesota, Minneapolis, Minnesota.

5. 5Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts.

6. 6Department of Physics, University of Alberta, Edmonton, Alberta, Canada.

7. 7Department of Neurosurgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts.

8. 8Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.

9. 9Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston Texas.

10. 10Neuroscience and Cancer Biology Graduate Programs, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences.

Abstract

Abstract Tumor treating fields (TTFields), a new modality of cancer treatment, are electric fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment of glioblastoma multiforme and mesothelioma, and they are currently under study in many other cancer types. While antimitotic effects were the first recognized biological anticancer activity of TTFields, data have shown that tumor treating fields achieve their anticancer effects through multiple mechanisms of action. TTFields therefore have the ability to be useful for many cancer types in combination with many different treatment modalities. Here, we review the current understanding of TTFields and their mechanisms of action.

Funder

HonorHealth

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/cancerres/article-pdf/doi/10.1158/0008-5472.CAN-22-0887/3180540/can-22-0887.pdf

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