Genetic Linkage of Prostate Cancer Risk to the Chromosome 3 Region Bearing <i>FHIT</i>-Reference-Cited by-同舟云学术

Genetic Linkage of Prostate Cancer Risk to the Chromosome 3 Region Bearing FHIT

Published:2005-02-01 Issue:3 Volume:65 Page:805-814
ISSN:0008-5472
Container-title:Cancer Research
language:en
Short-container-title:

Author:

Larson Garry P.¹,Ding Yan¹,Cheng Li S-C.²,Lundberg Cathryn¹,Gagalang Virgil¹,Rivas Guillermo¹,Geller Louis¹,Weitzel Jeffrey¹³,MacDonald Deborah³,Archambeau John⁴,Slater Jerry⁴,Neuberg Donna⁵,Daly Mary B.⁶,Angel Irene⁶,Benson Al B.⁷,Smith Kimberly⁸,Kirkwood John M.⁹,O'Dwyer Peter J.¹⁰,Raskay Barbara¹⁰,Sutphen Rebecca¹¹,Drew Rosalind¹¹,Stewart James A.¹²,Werndli Jae¹²,Johnson David¹³,Ruckdeschel John C.¹⁴,Elston Robert C.¹⁵,Krontiris Theodore G.¹

Affiliation:

1. 1Divisions of Molecular Medicine and

2. 2Information Sciences, Beckman Research Institute and

3. 3Department of Cancer Genetics, City of Hope National Medical Center, Duarte, California;

4. 4Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California;

5. 5Division of Biostatistics, Dana-Farber Cancer Institute, Harvard Medical School and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts;

6. 6Department of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania;

7. 7Department of Medicine, Division of Hematology/Oncology and

8. 8Clinical Research Office, Robert J. Lurie Comprehensive Cancer Center, Northwestern University School of Medicine, Chicago, Illinois;

9. 9Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania;

10. 10Department of Medicine, Hematology-Oncology Division, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania;

11. 11Interdisciplinary Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida;

12. 12University of Wisconsin Comprehensive Cancer Center and University of Wisconsin School of Medicine, Madison, Wisconsin;

13. 13Division of Hematology & Oncology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee;

14. 14Barbara Ann Karmanos Cancer Institute, Detroit, Michigan; and

15. 15Department of Epidemiology and Biostatistics, Case Western Reserve University, Metro Health Medical Center, Cleveland, Ohio

Abstract

Abstract We conducted linkage analysis of 80 candidate genes in 201 brother pairs affected with prostatic adenocarcinoma. Markers representing two adjacent candidate genes on chromosome 3p, CDC25A and FHIT, showed suggestive evidence for linkage with single-point identity-by-descent allele-sharing statistics. Fine-structure multipoint linkage analysis yielded a maximum LOD score of 3.17 (P = 0.00007) at D3S1234 within FHIT intron 5. For a subgroup of 38 families in which three or more affected brothers were reported, the LOD score was 3.83 (P = 0.00001). Further analysis reported herein suggested a recessive mode of inheritance. Association testing of 16 single nucleotide polymorphisms (SNP) spanning a 381-kb interval surrounding D3S1234 in 202 cases of European descent with 143 matched, unrelated controls revealed significant evidence for association between case status and the A allele of single nucleotide polymorphism rs760317, located within intron 5 of FHIT (Pearson's χ2 = 8.54, df = 1, P = 0.0035). Our results strongly suggest involvement of germline variations of FHIT in prostate cancer risk.

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/cancerres/article-pdf/65/3/805/2539849/805-814.pdf

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