Warburg Effect Reshapes Tumor Immunogenicity-Reference-Cited by-同舟云学术

Warburg Effect Reshapes Tumor Immunogenicity

Published:2024-04-24 Issue:13 Volume:84 Page:2043-2045
ISSN:0008-5472
Container-title:Cancer Research
language:en
Short-container-title:

Author:

Enríquez José A.¹²^ORCID,Mittelbrunn María³^ORCID

Affiliation:

1. Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. 1

2. Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Madrid, Spain. 2

3. Tissue and Organ Homeostasis Program, Cell-Cell Communication and Inflammation Unit, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain. 3

Abstract

Abstract Tumor cells rewire their metabolism to fulfill the demands of highly proliferative cells. This changes cellular metabolism to adapt to fuel and oxygen availability for energy production and to increase the synthesis capacity of building blocks for cell division and growth. In addition, the metabolic shift modulates the immunogenicity of the tumor cells. Recently, Mahmood and colleagues reported a connection between mitochondrial DNA mutations in cancer cells and their response to immunotherapy in a mouse model of melanoma.

Publisher

American Association for Cancer Research (AACR)

Link

https://aacrjournals.org/cancerres/article-pdf/doi/10.1158/0008-5472.CAN-24-1304/3445065/can-24-1304.pdf

Reference10 articles.

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2. The hallmarks of cancer metabolism: still emerging;Pavlova;Cell Metab,2022

3. Rapid evolution of animal mitochondrial DNA;Brown;Proc Natl Acad Sci U S A,1979

4. Mitochondrial DNA variation and cancer;Kopinski;Nat Rev Cancer,2021

5. Enhanced immunogenicity of mitochondrial-localized proteins in cancer cells;Prota;Cancer Immunol Res,2020