Affiliation:
1. 1Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.
Abstract
Summary:
In this issue of Blood Cancer Discovery, Nakanishi et al. uncover a critical role for the elevated activity of the translation initiation factor eIF5A in the malignant growth of MYC-driven lymphoma. eIF5A is posttranslationally modified by hypusination through MYC oncoprotein-mediated hyperactivation of the polyamine–hypusine circuit, which may represent a promising therapeutic target because an enzyme of this circuit that is required for hypusinating eIF5A proved to be essential for lymphoma development.
See related article by Nakanishi et al., p. 294 (4).
Publisher
American Association for Cancer Research (AACR)
Reference10 articles.
1. The MYC oncogene: the grand orchestrator of cancer growth and immune invasion;Dhanasekaran;Nat Rev Clin Oncol,2022
2. Burkitt's lymphoma;Roschewski;N Engl J Med,2022
3. Toward a new molecular taxonomy of diffuse large B-cell lymphoma;Ennishi;Cancer Discov,2020
4. The polyamine-hypusine circuit controls an oncogenic translational program essential for malignant conversion in MYC-driven lymphoma;Nakanishi;Blood Cancer Discov,2023;
5. Remaining mysteries of molecular biology: the role of polyamines in the cell;Miller-Fleming;J Mol Biol,2015
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