Affiliation:
1. 1Department of Developmental and Cell Biology, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California.
Abstract
Summary
Several approaches for overcoming immunotherapy resistance in pancreatic and colorectal cancer syngeneic models were assessed using heparin and immunotherapy. Beneficial responses were attributed to heparin-induced vascular normalization, ensuing CD8+ T-cell infiltration, and M1 macrophage polarization, suggesting the potential for heparin-anchored therapies in cold tumors such as pancreatic cancer.
See related article by Wei et al., p. 2525
Funder
Center for Strategic Scientific Initiatives, National Cancer Institute
Publisher
American Association for Cancer Research (AACR)