To Quiesce or Senesce, That Is the Question for Dedifferentiated Liposarcoma-Reference-Cited by-同舟云学术

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To Quiesce or Senesce, That Is the Question for Dedifferentiated Liposarcoma

Published:2024-01-04 Issue: Volume: Page:OF1-OF3
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Weiss Mia C.¹²^ORCID,Eulo Vanessa³^ORCID,Van Tine Brian A.¹²⁴^ORCID

Affiliation:

1. 1Washington University in St. Louis, School of Medicine, Department of Medicine, Division of Medical Oncology, St. Louis, Missouri.

2. 2Siteman Cancer Center, St. Louis, Missouri.

3. 3Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, Alabama.

4. 4Department of Pediatric Hematology/Oncology, St. Louis Children's Hospital, St Louis, Missouri.

Abstract

Summary Dedifferentiated liposarcoma (DDLPS) has an appealing therapeutic target due to its CDK4 amplification on chromosome 12q. The understanding of geroconversion from quiescent cells to senescent cells defines a patient's response to CDK4 inhibitors. This new observation will inform not only the ongoing phase III clinical trial of abemaciclib, but all future clinical trials in DDLPS. See related article by Gleason et al., p. xxx

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-23-2787/3390234/ccr-23-2787.pdf

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