Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies-Reference-Cited by-同舟云学术

Cancer's Dark Matter: Lighting the Abyss Unveils Universe of New Therapies

Published:2023-04-11 Issue:12 Volume:29 Page:2173-2175
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Fox Bernard A.¹²³^ORCID,Urba Walter J.¹^ORCID,Jensen Shawn M.¹^ORCID,Page David B.¹^ORCID,Curti Brendan D.¹^ORCID,Sanborn Rachel E.¹^ORCID,Leidner Rom S.¹^ORCID

Affiliation:

1. 1Robert W. Franz Cancer Center, Earle A. Chiles Research Institute, Providence Cancer Institute, Providence Portland Medical Center, Portland, Oregon.

2. 2Department of Molecular Microbiology and Immunology, and Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.

3. 3UbiVac, Portland, Oregon.

Abstract

SummaryThe authors of a recent study identified noncanonical peptides (NCP) presented by cancer cells’ HLA and observed lack of reactivity to these antigens by endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive T cells that recognized epitopes shared by a majority of cancers tested, providing opportunities for novel therapies to shared antigens.See related article by Lozano-Rabella et al., p. 2250

Funder

Shimadzu

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-23-0422/3322950/ccr-23-0422.pdf

Reference20 articles.

1. Exploring the immunogenicity of noncanonical HLA-I tumor ligands identified through proteogenomics;Lozano-Rabella;Clin Cancer Res,2023

2. Integrated proteogenomic deep sequencing and analytics accurately identify noncanonical peptides in tumor immunopeptidomes;Chong;Nat Commun,2020

3. The origin and immune recognition of tumor-specific antigens;Apavaloaei;Cancers,2020

4. Most non-canonical proteins uniquely populate the proteome or immunopeptidome;MV;Cell Rep,2021

5. Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer;Ouspenskaia;Nat Biotechnol,2022

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