Levetiracetam: A Potent Sword against Microglia Polarization in Gliomas-Reference-Cited by-同舟云学术

Levetiracetam: A Potent Sword against Microglia Polarization in Gliomas

Published:2024-01-03 Issue:6 Volume:30 Page:1073-1075
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Cui Xiaoteng¹²^ORCID,Wang Qixue¹²^ORCID,Liu Xiaomin³^ORCID,Kang Chunsheng¹²^ORCID

Affiliation:

1. 1Laboratory of Neuro-oncology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, P.R China.

2. 2Key Laboratory of Post-Neuro Injury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, P.R. China.

3. 3Neuro-Oncology Center, Tianjin Huanhu Hospital, Nankai University, Tianjin, P.R. China.

Abstract

Summary Crosstalk between tumor cells and peritumoral cells contributes to immunosuppressive microenvironment formation in glioblastomas (GBM). A recent study revealed that glioma stem cells activated neuronal activity to promote microglial M2 polarization, leading to GBM progression, which could be pharmacologically blocked by levetiracetam, providing a practical strategy for GBM immunotherapy. See related article by Guo et al., p. 1160

Funder

Tianjin Municipal Science and Technology Program

Special Project for Research and Development in Key areas of Guangdong Province

National Natural Science Foundation of China

Tianjin Municipal Health Commission

Publisher

American Association for Cancer Research (AACR)

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-23-3322/3398136/ccr-23-3322.pdf

Reference18 articles.

1. Hypoxia-induced neuronal activity in glioma patients polarizes microglia by potentiating RNA m6A demethylation;Guo;Clin Cancer Res,2024

2. Multidimensional communication in the microenvirons of glioblastoma;Broekman;Nat Rev Neurol,2018

3. Brain tumor microenvironment and host state: implications for immunotherapy;Tomaszewski;Clin Cancer Res,2019

4. Glutamate release by primary brain tumors induces epileptic activity;Buckingham;Nat Med,2011

5. Antidepressant therapies inhibit inflammation and microglial M1-polarization;Kalkman;Pharmacol Ther,2016

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. β-Mangostin targets and suppresses glioma via STING activation and tumor-associated microglia polarization;Biomedicine & Pharmacotherapy;2024-08