Prognosis to Radiation Unlocked: How Hypoxia Methylome May Hold the Key in HNSCC-Reference-Cited by-同舟云学术

Prognosis to Radiation Unlocked: How Hypoxia Methylome May Hold the Key in HNSCC

Published:2023-06-13 Issue:16 Volume:29 Page:2954-2956
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Heft Neal Molly E.¹^ORCID,Brenner J. Chad¹²³^ORCID

Affiliation:

1. 1Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.

2. 2University of Michigan Rogel Cancer Center, Ann Arbor, Michigan.

3. 3Department of Pharmacology, University of Michigan, Ann Arbor, Michigan.

Abstract

SummaryHypoxia in head and neck tumors has proven to be predictive of outcomes. Current hypoxia signatures have failed for patient treatment selection. In a recent study, the authors identified a hypoxia methylation signature as a more robust biomarker in head and neck squamous cell carcinoma and shed light into the mechanism of hypoxia-mediated treatment resistance.See related article by Tawk et al., p. 3051

Funder

National Institute of Dental and Craniofacial Research

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-23-1132/3339986/ccr-23-1132.pdf

Reference16 articles.

1. DNA-methylome based tumor hypoxia classifier identifies HPV-negative head and neck cancer patients at risk for locoregional recurrence after primary radiochemotherapy;Tawk;Clin Cancer Res,2023

2. The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer;Ragnum;Br J Cancer,2015

3. Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers;Winter;Cancer Res,2007

4. Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene;Buffa;Br J Cancer,2010

5. Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck;Toustrup;Radiother Oncol,2012

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