Unique Cabozantinib Dosing Considerations in People Living with HIV and Cancer-Reference-Cited by-同舟云学术

Unique Cabozantinib Dosing Considerations in People Living with HIV and Cancer

Published:2023-10-04 Issue:24 Volume:29 Page:4999-5001
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Eisenmann Eric D.¹^ORCID,Sparreboom Alex¹^ORCID

Affiliation:

1. 1Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio.

Abstract

SummaryA recent article characterized dosing recommendations for cabozantinib in people living with HIV (PLWH) and cancer, a group that is often excluded from clinical trials. This study suggests cabozantinib is effective in cancers disproportionately impacting PLWH and has translational implications for the design of studies evaluating drug-drug interactions.See related article by Haigentz et al., p. 5038

Funder

Center for Clinical and Translational Science, Ohio State University

Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-23-2351/3370619/ccr-23-2351.pdf

Reference20 articles.

1. Phase I trial of the multi-kinase inhibitor cabozantinib, a CYP3A4 substrate, plus CYP3A4-interacting antiretroviral therapy in people living with HIV and cancer (AMC-087);Haigentz;Clin Cancer Res,2023

2. Pharmacokinetic (PK) drug interaction studies of cabozantinib: effect of CYP3A inducer rifampin and inhibitor ketoconazole on cabozantinib plasma PK and effect of cabozantinib on CYP2C8 probe substrate rosiglitazone plasma PK;Nguyen;J Clin Pharmacol,2015

3. Cabozantinib in progressive medullary thyroid cancer;Elisei;J Clin Oncol,2013

4. Cabozantinib versus everolimus in advanced renal-cell carcinoma;Choueiri;N Engl J Med,2015

5. Pharmacokinetics of cabozantinib tablet and capsule formulations in healthy adults;Nguyen;Anticancer Drugs,2016