IL15 and IL21: Better When Membrane-Tethered Together on Antitumor T Cells-Reference-Cited by-同舟云学术

IL15 and IL21: Better When Membrane-Tethered Together on Antitumor T Cells

Published:2024-01-30 Issue:8 Volume:30 Page:1431-1433
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Ruffin Ayana T.¹²^ORCID,Wittling Megen C.¹²^ORCID,Cole Anna C.¹²^ORCID,Paulos Chrystal M.¹²^ORCID

Affiliation:

1. 1Department of Surgery, Emory University, Atlanta, Georgia.

2. 2Department of Microbiology and Immunology, Emory University, Atlanta, Georgia.

Abstract

Summary Systemic administration of homeostatic γ-chain cytokines mediates antitumor responses in some patients treated with adoptive immunotherapy. Yet many patients experience toxic side effects. New work presented herein suggests these limitations can be overcome by membrane-tethering IL15 and IL21 to T-cell products. This finding has major implications in advancing medicine. See related article by Nguyen et al., p. 1555

Funder

ARCs Foundation

Emory University Start Up Funds

National Cancer Institute

Melanoma Research Foundation

Publisher

American Association for Cancer Research (AACR)

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-23-3466/3411877/ccr-23-3466.pdf

Reference14 articles.

1. Cooperative armoring of CAR and TCR T-cells by T cell-restricted IL-15 and IL-21 universally enhances solid tumor efficacy;Nguyen;Clin Cancer Res,2024

2. IL15 and T-cell stemness in T-cell-based cancer immunotherapy;Pilipow;Cancer Res,2015

3. IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells;Klebanoff;Proc Natl Acad Sci USA,2004

4. Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells;Klebanoff;Proc Natl Acad Sci USA,2005

5. Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice;Klebanoff;Clin Cancer Res,2011