Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!-Reference-Cited by-同舟云学术

Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!

Published:2022-12-22 Issue:5 Volume:29 Page:833-834
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Ronchi Carlos¹^ORCID,Brisken Cathrin¹²^ORCID

Affiliation:

1. 1ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

2. 2The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

Abstract

SummaryThe presurgical window of opportunity trial (WOT) MIPRA provides evidence that neoadjuvant treatment with the progesterone receptor (PR) antagonist mifepristone (RU486) may benefit patients with estrogen receptor–positive (ER+) breast cancer characterized by a high ratio of PR-A versus PR-B isoform (>1.5), suggesting that PR may be targeted in a subset of patients.See related article by Elía et al., p. 866

Funder

H2020 Marie Skłodowska-Curie Actions

Breast Cancer Now

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-22-3374/3233041/ccr-22-3374.pdf

Reference17 articles.

1. Beneficial effects of mifepristone treatment in breast cancer patients selected by the progesterone receptor isoform ratio: results from the MIPRA trial;Elía;Clin Cancer Res,2023

2. Progesterone signaling in breast cancer: a neglected hormone coming into the limelight;Brisken;Nat Rev Cancer,2013

3. A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform;Sartorius;Mol Endocrinol,1994

4. Functional properties of the N-terminal region of progesterone receptors and their mechanistic relationship to structure;Takimoto;J Steroid Biochem Mol Biol,2003

5. Spatial definition of the human progesterone receptor-B transcriptional complex;Yu;iScience,2022