Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!

Author:

Ronchi Carlos1ORCID,Brisken Cathrin12ORCID

Affiliation:

1. 1ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

2. 2The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

Abstract

SummaryThe presurgical window of opportunity trial (WOT) MIPRA provides evidence that neoadjuvant treatment with the progesterone receptor (PR) antagonist mifepristone (RU486) may benefit patients with estrogen receptor–positive (ER+) breast cancer characterized by a high ratio of PR-A versus PR-B isoform (>1.5), suggesting that PR may be targeted in a subset of patients.See related article by Elía et al., p. 866

Funder

H2020 Marie Skłodowska-Curie Actions

Breast Cancer Now

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Reference17 articles.

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