Old Dog, New Trick: A Tumor-Intrinsic Role for PD-1 in Chemoresistant Tumor Subclones-Reference-Cited by-同舟云学术

Old Dog, New Trick: A Tumor-Intrinsic Role for PD-1 in Chemoresistant Tumor Subclones

Published:2022-11-16 Issue:3 Volume:29 Page:505-507
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Augustin Ryan C.¹²^ORCID,Bao Riyue¹²^ORCID,Luke Jason J.¹²^ORCID

Affiliation:

1. 1UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.

2. 2University of Pittsburgh, Department of Medicine, Pittsburgh, Pennsylvania.

Abstract

SummaryProgrammed cell death protein 1 (PD-1) is a well-known driver of immunosuppression and lymphocyte-associated disease progression. Increasing evidence suggests a tumor-intrinsic role for PD-1 in promoting chemoresistance via stem-like features. Moving forward, a recent study implies a novel antitumor mechanism for PD-1 inhibition.See related article by Rotolo et al., p. 621

Funder

National Institutes of Health

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-22-3022/3225224/ccr-22-3022.pdf

Reference20 articles.

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2. Melanoma cell-intrinsic PD-1 receptor functions promote tumor growth;Kleffel;Cell,2015

3. Regulation of PD-L1: a novel role of pro-survival signaling in cancer;Chen;Ann Oncol,2016

4. PD-L1 as a biomarker of response to immune checkpoint inhibitors;Doroshow;Nat Rev Clin Oncol,2021

5. Immune checkpoint blockade in cancer therapy;Postow;J Clin Oncol,2015

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1. PD-1 receptor outside the main paradigm: tumour-intrinsic role and clinical implications for checkpoint blockade;British Journal of Cancer;2023-07-20

2. Chemotherapy-induced PDL-1 expression in cancer-associated fibroblasts promotes chemoresistance in NSCLC;Lung Cancer;2023-07