Insulin-Like Growth Factor-I and Breast Cancer Therapy-Reference-Cited by-同舟云学术

Insulin-Like Growth Factor-I and Breast Cancer Therapy

Published:2005-01-15 Issue:2 Volume:11 Page:944s-950s
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Ibrahim Yasir H.¹,Yee Douglas¹

Affiliation:

1. University of Minnesota Cancer Center, Minneapolis, Minnesota

Abstract

Abstract Targeting hormonal and growth factor signaling pathways has proven to be useful in the treatment of breast cancer. In vitro, animal, and epidemiologic evidence provide a rationale for the relevance of the insulin-like growth factor (IGF) system to breast cancer biology. The IGF system has been implicated in promoting mitogenic, metastatic, and antiapoptotic phenotypes in breast cancer. As a consequence of the ability of IGF to promote tumorigenesis, pharmacologic interventions targeting the IGF system are being devised. Such strategies include decreasing ligand production, ligand binding, or receptor activation. In this article, directed anti-IGF strategies and the possible clinical impact of using such therapies for treating breast cancer are discussed.

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/clincancerres/article-pdf/11/2/944s/1961881/944s-950s.pdf

Reference80 articles.

1. Salomon W, Daughaday W. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med 1957;49:825–36.

2. Laron Z, Pertzelan A, Mannheimer S. Genetic pituitary dwarfism with high serum concentration of growth hormone—a new inborn error of metabolism? Isr J Med Sci 1966;2:152–5.

3. Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst 2000;92:1472–89.

4. Werner H, Woloschack M, Stannard B, Shen-Orr Z, Roberts C, LeRoith D. The insulin-like growth factor receptor: molecular biology, heterogeneity, and regulation. In: LeRoith D, editor. Insulin-like growth factors: molecular and cellular aspects. Boca Raton: CRC Press; 1991. p.18–48.

5. Baserga R. The IGF-IR receptor in normal and abnormal growth. In: Hormones and growth factors in development and neoplasia. New York: Wiley-Liss; 1998. p. 269–87.