Feasibility of methotrexate discontinuation following tocilizumab and methotrexate combination therapy in patients with long-standing and advanced rheumatoid arthritis: a 3-year observational cohort study

Author:

Miyata Masayuki1,Hirabayashi Yasuhiko2,Munakata Yasuhiko3,Urata Yukitomo4,Saito Koichi5,Okuno Hiroshi6,Yoshida Masaaki7,Kodera Takao8,Watanabe Ryu9,Miyamoto Seiya10,Ishii Tomonori11,Nakazawa Shigeshi12,Takemori Hiromitsu13,Ando Takanobu14,Kanno Takashi15,Komagamine Masataka16,Kato Ichiro6,Takahashi Yuichi17,Komatsuda Atsushi18,Endo Kojiro19,Murai Chihiro20,Takakubo Yuya21,Miura Takao22,Sato Yukio23,Ichikawa Kazunobu24,Konta Tsuneo25,Chiba Noriyuki26,Muryoi Tai27,Kobayashi Hiroko28,Fujii Hiroshi11,Sekiguchi Yukio29,Hatakeyama Akira6,Ogura Ken30,Sakuraba Hirotake31,Asano Tomoyuki32,Kanazawa Hiroshi13,Suzuki Eiji15,Takasaki Satoshi33,Asakura Kenichi34,Suzuki Yoko35,Takagi Michiaki21,Nakayama Takahiro36,Watanabe Hiroshi32,Miura Keiki37,Mori Yu38,

Affiliation:

1. Department of Internal Medicine, Fukushima Red Cross Hospital

2. Department of Rheumatology, Hikarigaoka Spellman Hospital

3. Munakata Yasuhiko Clinic

4. Department of Rheumatology, Tsugaru General Hospital

5. Suminoya Rheumatism & Orthopedics Clinic

6. Department Orthopedic Surgery, Tohoku Rosai Hospital

7. Yoshida Orthopedic Surgery and Rheumatology Clinic

8. Center for Arthritis and Rheumatic Diseases, Tohoku Pharmaceutical University Hospital

9. Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University

10. Department of Orthopedic Surgery, Tohoku Orthopedic Clinic

11. Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine

12. Nakazawa Sports Clinic

13. Department of Rheumatology, Aomori Prefectural Central Hospital

14. Department of Orthopedics, General Hanamaki Hospital

15. Department of Rheumatology, Ohta Nishinouchi Hospital

16. Komagamine Orthopedic and Rheumatology Clinic

17. Yu Family Clinic

18. Department of Internal Medicine, Ogachi Central Hospital

19. Department of Rheumatology and Department of Orthopedic Surgery, Hoshi General Hospital

20. Murai Clinic

21. Department of Orthopedic Surgery, Yamagata University Faculty of Medicine

22. Department of Orthopedic Surgery, Hirosaki Memorial Hospital

23. Department of Rheumatology, Kaiyama Central Hospital

24. Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine

25. Department of Public Health and Hygiene/Nephrology and Collagen Disease

26. Department of Internal Medicine, Morioka National Hospital

27. Muryoi Clinic

28. Minami-Fukushima Clinic

29. NTT East Tohoku Hospital

30. Ogura Orthopedic Surgery Clinic

31. Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine

32. Department of Rheumatology and Collagen Disease, Fukushima Medical University Hospital

33. Department of Internal Medicine, Saiseikai Yamagata Hospital

34. Department of Internal Medicine, Yuri Kumiai General Hospital

35. Izumi Himawari Clinic

36. Department of Internal Medicine, Nihonkai General Hospital

37. Department of Orthopedic Surgery, Wakuya-Town National Health Insurance Hospital

38. Department of Orthopedic Surgery, Tohoku University Graduate School of Medicine

Publisher

The Fukushima Society of Medical Science

Subject

General Medicine

Reference20 articles.

1. 1. Smolen JS, Landewé RBM, Bijlsma JWJ, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs:2019 update. Ann Rheum Dis, 79:685-699, 2020. https://doi.org/10.1136/annrheumdis-2019-216655.

2. 2. Kerschbaumer A, Sepriano A, Smolen JS, et al. Efficacy of pharmacological treatment in rheumatoid arthritis:A systematic literature research informing the 2019 update of the EULAR recommendations for management of rheumatoid arthritis. Ann Rheum Dis, 79:744-759, 2020. https://doi.org/10.1136/annrheumdis-2019-216656.

3. 3. Nam JL, Winthrop KL, van Vollenhoven RF, et al. Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs:a systematic literature review informing the EULAR recommendations for the management of RA. Ann Rheum Dis, 69:976-986, 2010. https://doi.org/10.1136/ard.2009.126573.

4. 4. Silvagni E, Bortoluzzi A, Carrara G, Zanetti A, Govoni M, Scirè CA. Comparative effectiveness of first-line biological monotherapy use in rheumatoid arthritis:a retrospective analysis of the RECord-linkage On Rheumatic Diseases study on health care administrative database. BMJ Open. 2018;8:e021447. http://dx.doi.org/10.1136/bmjopen-2017-021447.

5. 5. Finzel S, Kraus S, Figueiredo CP, et al. Comparison of the effects of tocilizumab monotherapy and adalimumab in combination with methotrexate on bone erosion repair in rheumatoid arthritis. Ann Rheum Dis, 78:1186-1191, 2019. https://doi.org/10.1136/annrheumdis-2018-214894.

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