Utility of Transgenic Mice Carrying Human Prototype c-Ha-ras Gene for Alternative Carcinogenicity Testing of Chemicals. Negative Results with Methapyrilene Hydrochloride.
Author:
Affiliation:
1. Department of Oncological Pathology, Cancer Center, Nara Medical University, 840, Shijo-cho, Kashihara-shi, Nara 634-8521, Japan
2. Medical Research Laboratories, Wyeth Lederle Japan, Ltd., 1-6-34, Kashiwa-cho, Shiki-shi, Saitama 353-8511, Japan
Publisher
Japanese Society of Toxicologic Pathology
Subject
Toxicology,Pathology and Forensic Medicine
Link
http://www.jstage.jst.go.jp/article/tox/13/3/13_3_179/_pdf
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4. Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA
5. Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice
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