Karnovsky’s fixative prevents artifacts appearing as vacuolation derived from tissue processing in kidneys treated with antisense oligonucleotide
Author:
Affiliation:
1. Safety Research Laboratories, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-26-1 Muraoka-Higashi, Fujisawa, Kanagawa 251-8555, Japan
Publisher
Japanese Society of Toxicologic Pathology
Subject
Toxicology,Pathology and Forensic Medicine
Link
https://www.jstage.jst.go.jp/article/tox/34/4/34_2021-0007/_pdf
Reference14 articles.
1. 1. Rinaldi C, and Wood MJA. Antisense oligonucleotides: the next frontier for treatment of neurological disorders. Nat Rev Neurol. 14: 9–21. 2018.
2. 2. Uemura Y, and Kobayashi K. Targeting murine alveolar macrophages by the intratracheal administration of locked nucleic acid containing antisense oligonucleotides. Drug Deliv. 26: 803–811. 2019.
3. 3. Bennett CF. Therapeutic antisense oligonucleotides are coming of age. Annu Rev Med. 70: 307–321. 2019.
4. 4. Frazier KS. Antisense oligonucleotide therapies: the promise and the challenges from a toxicologic pathologist’s perspective. Toxicol Pathol. 43: 78–89. 2015.
5. 5. Engelhardt JA. Comparative renal toxicopathology of antisense oligonucleotides. Nucleic Acid Ther. 26: 199–209. 2016.
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