Evaluation of potential activity of luseogliflozin on vascular proliferation in the mesenteric lymph node with or without vascular tumors in Sprague-Dawley rats in a carcinogenicity study
Author:
Affiliation:
1. Drug Safety, Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama-shi, Saitama 331-9530, Japan
Publisher
Japanese Society of Toxicologic Pathology
Subject
Toxicology,Pathology and Forensic Medicine
Link
https://www.jstage.jst.go.jp/article/tox/29/2/29_2015-0054/_pdf
Reference28 articles.
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2. 2. Radi ZA, and Morton D. Human safety risk assessment of lymph node angiomas observed in 2-year carcinogenicity studies in rats. Regul Toxicol Pharmacol. 64: 435–441. 2012.
3. 3. Wright EM, Hirayama BA, and Loo DF. Active sugar transport in health and disease. J Intern Med. 261: 32–43. 2007.
4. 4. Kakinuma H, Oi T, Hashimoto-Tsuchiya Y, Arai M, Kawakita Y, Fukasawa Y, Iida I, Hagima N, Takeuchi H, Chino Y, Asami J, Okumura-Kitajima L, Io F, Yamamoto D, Miyata N, Takahashi T, Uchida S, and Yamamoto K. (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4- methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment. J Med Chem. 53: 3247–3261. 2010.
5. 5. Pharmaceuticals and Medical Devices Agency of JAPAN (PMDA) Luseogliflozin CTD part2. 2014, from PMDA website: http://www.pmda.go.jp/drugs/2014/P201400033/index.html.
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