A Reliable Method for Intratracheal Instillation of Materials to the Entire Lung in Rats

Author:

Oka Yasuo1,Mitsui Masayuki2,Kitahashi Tsukasa3,Sakamoto Akika3,Kusuoka Osamu2,Tsunoda Tsukasa1,Mori Toshio3,Tsutsumi Masahiro34

Affiliation:

1. Department of Surgery, Division of Gastroenterology, Kawasaki Medical University

2. Department of Molecular Pathology, Nara Medical University

3. RI Center, Nara Medical University

4. Saiseikai Chuwa Hospital

Publisher

Japanese Society of Toxicologic Pathology

Subject

Toxicology,Pathology and Forensic Medicine

Reference8 articles.

1. 1. Umbert S, Francesco C, and Leonard HK. A method for the experimental induction of bronchogenic carcinoma. Cancer Res. 28: 104-124. 1968.

2. 2. Morrow WG. A method for intratracheal instillation in the rat. Lab Anim Sci. 25: 337-340. 1975.

3. 3. Davis BR, Whitehead JK, Gill ME, Lee PM, Butterworth AD, and Roe FJ. Response of rat lung to tobacco smoke condensate or fractions derived from it administered repeatedly by intratracheal instillation. Br J Cancer. 31: 453-461. 1975.

4. 4. Schreiber H, Martin DH, and Pazmino N. Species differences in the effect of benzo (a) pyrene-ferric oxide on the respiratory tract of rats and hamsters. Cancer Res. 35: 1654-1661. 1975.

5. 5. Steinhoff D, Gad SC, Hatfield GK, and Mohr U. Carcinogenicity study with sodium dichromate in rats. Exp Pathol. 30: 129-141. 1986.

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