N-Ethyl-N-Nitrosourea Induces Retinal Photoreceptor Damage in Adult Rats

Author:

Yoshizawa Katsuhiko1,Sasaki Tomo12,Uehara Norihisa1,Kuro Maki3,Kimura Ayako1,Kinoshita Yuichi14,Miki Hisanori1,Yuri Takashi1,Tsubura Airo1

Affiliation:

1. Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan

2. Kyoto R & D Center, Maruho Co., Ltd., Kyoto, Kyoto 600-8815, Japan

3. Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka 570-8507, Japan

4. Department of Cytopathology, Kansai Medical University Takii Hospital, Moriguchi, Osaka 570-8507, Japan

Publisher

Japanese Society of Toxicologic Pathology

Subject

Toxicology,Pathology and Forensic Medicine

Reference43 articles.

1. 1. Diwan BA. Strain-dependent teratogenic effects of 1-ethyl-1-nitrosourea in inbred strains of mice. Cancer Res. 34: 151-157. 1974.

2. 2. Nagaishi T. Effects of ethylnitrosourea on the developing rat retina. Nippon Ganka Gakkai Zasshi. 86: 1224-1235. 1982(Abstract in English, text in Japanese).

3. 3. World Health Organization, International Agency for Research on Cancer (WHO IARC). N-nitroso-N-ethylurea. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 17, Some N-Nitroso Compounds, IARC Scientific Publications, Lyon, France. 191. 1998.

4. 4. Probst FJ, and Justice MJ. Mouse mutagenesis with the chemical supermutagen ENU. Methods Enzymol. 477: 297-312. 2010.

5. 5. Wagner S, Calzada-Wack J, Rosemann M, Becher L, Tost M, Silva-Buttkus P, Klein-Rodewald T, Fuchs H, Neff F, Hrabe de Angelis M, and Esposito I. Characterization of ENU-mutant mice. Animal models for human diseases using morphological and molecular methods. Pathologe. (Suppl 2): 147-152. 2010 (Abstract in English, text in German).

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