A Case of Spontaneous Malignant Hibernoma in a Crl:CD(SD)IGS Rat

Author:

Anagawa Akiko1,Okazaki Yoshimasa1,Murakami Yuichi1,Tsubota Kenjiro1,Ono Mihoko1,Matsumoto Masahiro1,Nakatsuji Shunji1,Oishi Yuji1

Affiliation:

1. Drug Safety Research Laboratories, Astellas Pharma Inc.

Publisher

Japanese Society of Toxicologic Pathology

Subject

Toxicology,Pathology and Forensic Medicine

Reference12 articles.

1. 1. Poulet FM, Berardi MR, Halliwell W, Hartman B, Auletta C, and Bolte H. Development of hibernomas in rats dosed with phentolamine mesylate during the 24-month carcinogenicity study. Toxicol Pathol. 32: 558-566. 2004.

2. 2. Chandra S, Dochterman W, Ploch S, Torrey C, Cummings CA, Peterson R, et al. A carcinogenicity study with unusually high incidence of spontaneous hibernomas in Wistar-Han rats. Society of Toxicologic Pathology, annual meeting, San Francisco, CA. Poster No.14. 2008.

3. 3. Coleman GL. Four intrathoracic hibernomas in rats. Vet Pathol. 17: 634-637. 1980.

4. 4. Stefanski SA, Elwell MR, and Yoshitomi K. Malignant hibernoma in a Fischer 344 rat. Lab Anim Sci. 37: 347-350. 1987.

5. 5. Al Zubaidy AJ and Finn JP. Brown fat tumours (hibernomas) in rats: histopathological and ultrastructural study. Lab Anim. 17: 13-17. 1983.

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