Chemical-induced lung tumor in Tg-rasH2 mice: a novel mouse tumor model to assess immune checkpoint inhibitors combined with a chemotherapy drug

Author:

Hagiwara Teruaki1,Numano Takamasa1,Hara Tomomi1,Sugiyama Taiki1,Mera Yukinori1,Tamano Seiko1,Miyata Hiroto1

Affiliation:

1. DIMS Institute of Medical Science, Inc., 64 Goura, Nishiazai, Azai-cho, Ichinomiya-shi, Aichi 491-0113, Japan

Publisher

Japanese Society of Toxicologic Pathology

Subject

Toxicology,Pathology and Forensic Medicine

Reference58 articles.

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2. 2. Hirsch FR, Scagliotti GV, Mulshine JL, Kwon R, Curran WJ Jr, Wu YL, and Paz-Ares L. Lung cancer: current therapies and new targeted treatments. Lancet. 389: 299–311. 2017.

3. 3. Steven A, Fisher SA, and Robinson BW. Immunotherapy for lung cancer. Respirology. 21: 821–833. 2016.

4. 4. Devaud C, Westwood JA, John LB, Flynn JK, Paquet-Fifield S, Duong CP, Yong CS, Pegram HJ, Stacker SA, Achen MG, Stewart TJ, Snyder LA, Teng MW, Smyth MJ, Darcy PK, and Kershaw MH. Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy. Mol Ther. 22: 18–27. 2014.

5. 5. Daniel VC, Marchionni L, Hierman JS, Rhodes JT, Devereux WL, Rudin CM, Yung R, Parmigiani G, Dorsch M, Peacock CD, and Watkins DN. A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro. Cancer Res. 69: 3364–3373. 2009.

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