Lack of hepatocarcinogenicity of 2,2’-[1,2-ethanediylbis(oxymethylene)]bis-oxirane, 3-hydroxy-2-naphthoic acid, and acetoacetanilide in a medium-term rat liver bioassay

Author:

Yamagata Hiroshi1,Saito Tsubasa2,Okamoto Takezo1,Satomoto Kensuke1,Mitsumoto Tatsuya1,Wakita Atsushi3,Nakamura Maki4,Hayashi Takahiro4,Kuroiwa Yuichi1

Affiliation:

1. Toxicology Division, Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan

2. Pathology Division, Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan

3. Toxicology Division, Tokyo Laboratory, BoZo Research Center Inc., 1-3-11 Hanegi, Setagaya-ku, Tokyo 156-0042, Japan

4. Clinical Pathology Division, Tsukuba Research Institute, BoZo Research Center Inc., 8 Okubo, Tsukuba-shi, Ibaraki 300-2611, Japan

Publisher

Japanese Society of Toxicologic Pathology

Subject

Toxicology,Pathology and Forensic Medicine

Reference20 articles.

1. 1. JECDB Japan Existing Chemical Database, National Institute of Health Sciences: Reverse mutation test of 2,2’-[1,2-ethanediylbis(oxymethylene)]bis-oxirane (CAS No. 2224-15-9) (in Japanese). 2011, from JECDB website: https://dra4.nihs.go.jp/mhlw_data/home/pdf/PDF2224-15-9e.pdf

2. 2. JECDB Japan Existing Chemical Database, National Institute of Health Sciences: Chromosomal aberration test of 2,2’-[1,2-ethanediylbis(oxymethylene)]bis-oxirane (CAS No. 2224-15-9) (in Japanese). 2011, from JECDB website: https://dra4.nihs.go.jp/mhlw_data/home/pdf/PDF2224-15-9f.pdf

3. 3. MHLW Results of mutagenicity tests from the Workplace Safety Site in Ministry of Health, Labour and Welfare of Japan: negative result, reverse mutation test of 3-Hydroxy-2-naphthoic acid (CAS No. 92-70-6) (in Japanese). 2021, MHLW website: https://anzeninfo.mhlw.go.jp/user/anzen/kag/pdf/B/B92-70-6a.pdf

4. 4. MHLW Results of mutagenicity tests from the Workplace Safety Site in Ministry of Health, Labour and Welfare of Japan: positive result, reverse mutation tests of 3-Hydroxy-2-naphthoic acid (CAS No. 92-70-6) (in Japanese). 2021, from MHLW website: https://anzeninfo.mhlw.go.jp/user/anzen/kag/pdf/B/B92-70-6b.pdf

5. 5. MHLW Results of mutagenicity tests from the Workplace Safety Site in Ministry of Health, Labour and Welfare of Japan: chromosomal aberration test of 3-Hydroxy-2-naphthoic acid (CAS No. 92-70-6) (in Japanese). 2021, from WHLW website: https://anzeninfo.mhlw.go.jp/user/anzen/kag/pdf/C/C92-70-6.pdf

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