ACUTE TOXICITY TEST OF SKIN MANGOSTEEN (GARCINIA MANGOSTANA L.) AND HISTOPATHOLOGIC STUDY OF LIVER

Abstract

    The purpose of writing was to examine the toxicity acute mangosteen skin (Garcinia mangostana L.) and histopathologic study of liver. Animals in this study was 2 weeks old chickens with an average weight of 500 grams were divided into the test group; distilled water (blank), doses of 250, 500.1000, 2000.4000 mg/kg body weight. Chicken were housed in individual cages and given food and drink ad libitum. Acute toxicity tests performed on experimental animals. Giving the toxic dose in the treatment group performed one (single dosage) by intragastric using a stomach tube. The control group was force-fed with physiological saline. Acute toxicity tests performed on experimental animals. Giving the toxic dose in the treatment group performed one (single dosage) by intragastric using a stomach tube. On histopathological examination of liver in the test toksikasi mangosteen rind extract the microscopic changes that occur are cell degeneration and necrosis of hepatocytes. In the treatment group occurred degeneration that occurs in hepatocyte cell degeneration grained and hidrops. Extract of mangosteen rind has a broad safety index and does not cause high mortality in administration. Mangosteen rind extract that does not cause cellular toxicity reaction in the delivery of 100 doses.