Clinico-haematological effect of selected NSAID in the treatment of experimentally produced myositis in goat

Abstract

The present study was performed in the Department of Medicine and in Veterinary clinic of Bangladesh Agricultural University (BAU), Mymensingh from January to June 2002. Myositis was produced experimentally by injecting oil of turpentine in the gluteal muscles of 4 goats of which 2 goats were given treatment with Diclofenac sodium @1mg/kg body weight (treatment group) for consecutive 3 days and remaining 2 goats were reared as control without giving treatment (control group). All the goats were observed for 7 days. Myositis was characterized by reduced appetite, increased body temperature (1-2°F), lameness, local swelling and cellular changes in blood level. The appetite in both groups reduced sharply from 1st day of myositis and improved from day 2 and became normal on 3rd day after treatment. Body temperature reduced to normal level from 2nd day after administration of diclofenac sodium but in control group, it came down in the same condition from 4th day onward. Moderate lameness was observed in all the goats of both groups. In treatment group lameness reduced completely in 100% goats after 2 consecutive days of treatment but in control group similar result was observed on day 6. Moderate local swelling was reduced to normal level in treatment group 2 days post treatment remain moderate in control group. Total leukocyte count (TLC) was increased significantly (p < 0.05) in both groups in myositic condition than in healthy condition and it came down to normal level in treatment group 3 days post treatment and in control group it remained higher. Similar changes were observed in Neutrophil count. The number of lymphocyte was reduced significantly (p < 0.05) in myositic condition than in healthy ones which again reached to normal level within 3 days of treatment. Key words: Myositis, goat, Non-steroidal anti-inflammatory drug (NSAID) DOI = 10.3329/bjvm.v6i1.1345 Bangl.  J. Vet. Med. (2008). 6 (1): 99-102