Enhancement of cognitive performance in mice and in vitro acetyl-cholinesterase inhibitory activity of 3,3’,4’,5,7-pentahydroxyflavone isolated from Cadaba indica

Abstract

<p class="Abstract"><em>Cadaba indica</em>, a component of traditional siddha medicine, is used for the therapy of gonorrhea, inflammation, eczema etc. The present study shows that it exhibited acetylcholinesterase inhibitory activity (up to 81.5 ± 1.5%) at the concentration of 3 mg/mL, with the IC₅₀value of 1.8 mg/mL. Furthermore, the ethanol extract of<em> C. indica</em> therapy at a dose of 100 mg/kg p.o significantly ameliorated the cognitive impaired mice in Y-maze task. The active ingredient was identified as 3,3’,4’,5,7-pentahydroxyflavone. The above results suggest that <em>C. indica</em> would be a potential natural therapeutic remedy for cognitive disorders mediated by cholinergic dysfunction.</p><p class="Abstract"><strong>Video Clip:</strong></p><p class="Abstract"><a href="https://youtube.com/v/QIEuwPT-lmw">Memory impairment test in mice</a>: 1 min</p><p> </p>