Hepatoprotective effect of Monotheca buxifolia fruit against antitubercular drugs-induced hepatotoxicity in rats

Abstract

<p class="Abstract">The present study investigates the hepatoprotective potential of <em>Monotheca buxifolia</em> fruit hydro-ethanolic extract, against isoniazid- and rifampicin- induced hepatotoxicity in rats. Phytochemical investigations lead to the isolation of oleanolic acid and isoquercetin. Pretreatment with <em>M. buxifolia</em> extract at doses of 150 and 300 mg/kg for 21 days, restored the isoniazid- and rifampicin-induced elevation of serum levels of alanine aminotransferase (p&lt;0.001), aspartate aminotransferase (p&lt;0.001 and p&lt;0.05), alkaline phosphatase (p&lt;0.001), billirubin (p&lt;0.001) and total proteins (p&lt;0.001) as well as afforded significant protection against histopathological changes in the liver. From these results, it is conceivable that <em>M. buxifolia</em> exhibited selective protective effect against isoniazid- and rifampicin-induced hepatotoxicity, mediated through the presence of oleanolic acid and isoquercetin.</p><p> </p>