Effects of hydroalcoholic extract of Borago officinalis on naloxone-precipitated withdrawal syndrome in morphine-dependent mice

Abstract

<p class="Abstract">The aim of the present study was to investigate the effect of hydroalcoholic extract of <em>Borago officinalis</em> on morphine withdrawal syndrome in mice. Morphine-dependent group received morphine for nine days and then received naloxone via intraperitoneal injection.  Control group received saline for nine days. Post-treated group received <em>B. </em>officinalis extract intraperitoneally (100 mg/kg) on the day 10 before naloxone injection. Co-treated group received <em>B. </em>officinalis extract intraperitoneally (100 mg/kg) and morphine for nine days and then received naloxone. Extract-treated group received extract for nine days and then received naloxone. Naloxone injection significantly increased the frequency of jumping, blinking, ptosis, defecation, paw trembling, and two-legged standing in comparison to the control group. Co-treatment and post-treatment with <em>B. officinalis</em> extract significantly decreased the withdrawal symptoms. In conclusion, hydroalcoholic extract of <em>B. </em>officinalis significantly attenuated the symptoms of morphine withdrawal syndrome.</p><p><strong>Video Clip</strong>:</p><p><a href="https://youtube.com/v/TCNzTxZeGjw">Part 1</a>: 8 min 11 sec </p>