Antidiabetic potential of Gaultheria trichophylla in mice

Abstract

<p>This study evaluated <em>Gaultheria trichophylla</em> for its <em>in vitro</em> and <em>in vivo</em> anti-diabetic activity and its effect on biochemical parameters. The extract inhibited α-glucosidase with IC₅₀= 17.5 ± 0.1 μg/mL). The difference of body weight of the extract-treated diabetic groups and diabetic control was significant (p&lt;0.05). The extract-treated and the standard-treated groups showed significant (p&lt;0.001) decrease in the fasting blood glucose levels compared to diabetic control. The extract-treated groups after 15 days of treatment showed a significance (p&lt;0.001 and p&lt;0.05) decrease of the urea and creatinine levels respectively. The extract and standard-treated diabetic groups showed a significant decreased in the serum level of cholesterol, LDL, and triglycerides compared to the diabetic control group (p&lt;0.001). The extract and standard drug showed a significance improvement of HDL level in diabetic mice compared to the diabetic control (p&lt;0.001).</p><p><strong>Video Clip of Methodology</strong>:</p><p>2 min 49 sec:   <a href="https://www.youtube.com/v/l8cU2wT953w">Full Screen</a>   <a href="https://www.youtube.com/watch?v=l8cU2wT953w">Alternate</a></p>