Antibacterial and anti-hemolytic activity of tannins from Pimenta dioica against methicillin resistant Staphylococcus aureus

Abstract

<p class="Abstract">High rate of resistance among <em>Staphylococcus</em> infection initiates scientists to discover new antibiotics. The objective of this study is to determine the effect of tannins isolated from the <em>Pimenta dioica</em> leaves on <em>Staphylococcus aureus</em> and methicillin resistant <em>S. aureus</em> as well as to evaluate their effect on hemolysin production. The antimicrobial activity of 4,6-(S)-hexahydroxydiphenoyl-(α/β)-D-glucopyranose and casuarinin, pedunculagin and nilocitin tannins from <em>P. </em>dioica was examined using agar diffusion method. Moreover, minimum inhibitory concentrations were evaluated by microtiter plate assay method. Pedunculagin and nilocitin exhibited antibacterial and anti-hemolytic effect against <em>S. aureus</em>. This will open the era for<em> in vivo</em> assessment of such compounds for clinical applications.</p>