THE ROLE OF 1,25(OH)2D3 AND ITS ANALOGS IN PROLIFERATION AND DIFFERENTIATION OF SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK – LITERATURE REVIEW

Author:

Mizgalski Mateusz1,Zub Krzysztof1,Dorobisz Karolina1,Zatoński Tomasz1

Affiliation:

1. DEPARTMENT OF OTOLARYNGOLOGY - HEAD AND NECK SURGERY, MEDICAL UNIVERSITY OF WROCLAW, WROCLAW, POLAND

Abstract

Epidemiological studies correlate sun or UV light exposure with a lower incidence of a variety of malignancies, including breast, colon and prostate cancer. The biologically active 1,25(OH)2D3 and its analogs have been shown to have antiproliferative and differentiating effects in a variety of malignant and non-malignant cells. The effects of 1,25(OH)2D3 are mediated by the binding of calcitriol to a specific intracellular receptor, vitamin D receptor [VDR]. The aim of this study is to review the literature concerning the role of 1,25(OH)2D3 and its analogs in squamous carcinoma cell lines of the head and neck (SCCHN).

Publisher

ALUNA

Subject

General Medicine

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