Biological Effects of the most Common food Additives

Abstract

Aim: The paper was aimed at the study of foreign and domestic publications on the ef f ect of Sodium nitrite (E 250) food additive and Ponceau 4R (E124) food colorant on the body organs to form the concept of further research on the effects of complex food additives on the organs of the digestive system. Materials and methods: In the course of research, the following techniques have been used: bibliosemantic method for the analysis of scientific publications. The paper provides assessment of 70 literary sources. Particular attention is paid to sources over the last 5 years (2016-2021), but some earlier publications that have not lost their relevance are also included in the review. The sources were taken from scientific metric databases Scopus, Web of Science, PubMed, Medline, Google Scholar and the portal of scientific periodicals of V.I. Vernadsky National Library of Ukraine. Conclusions: Sodium nitrite has a detrimental toxic ef f ect on various organs of the body, which on the part of the urinary system is manifested by renal dysfunction, oxidative stress, inf l ammation and apoptosis, the immune system responds by suppressing T-cell immunity and increased migration of neutrophils into tissues from the heart-vascular system was observed vasodilation of the resistive link with a decrease in the rhythm of their vasomotion, venular hypertension, increased arteriole-venular shunting, tortuosity of blood vessels, general slowing of blood fl ow, stasis of erythrocyte aggregation with paravasal tissue edema. Sodium nitrite has the ability to attach to blood cells and interfere with the transport of oxygen. Solutions of the studied food dyes and their mixtures in acceptable daily concentrations changed the immediate and delayed secretion of cytokines by leukocytes in the blood of patients with allergies.